Medical Gas Research

RESEARCH ARTICLE
Year
: 2020  |  Volume : 10  |  Issue : 4  |  Page : 155--162

Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men


Yudai Shibayama1, Shohei Dobashi2, Takaaki Arisawa3, Tamotsu Fukuoka3, Katsuhiro Koyama4 
1 Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi, Japan
2 Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Yamanashi; Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan
3 Helix Japan Co., Ltd., Tokyo, Japan
4 Graduate School Department of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan

Correspondence Address:
PhD Katsuhiro Koyama
Graduate School Department of Interdisciplinary Research, University of Yamanashi, Yamanashi
Japan

Molecular hydrogen has been suggested to have a cytoprotective effect on the whole body and to enhance exercise performances. However, the effect of hydrogen-rich gas mixture (HG) inhalation on physiological responses has been poorly investigated. We examined the impact of acute HG inhalation on subsequent oxidative stress, muscle damage, and exercise performances during the recovery period after a strenuous exercise. This is a two-trial, double-blind, crossover, repeated measures study. Eight physically active male volunteers inhaled HG (estimated fraction of inspired oxygen and hydrogen were 21.57 and 4.08% at most, respectively) or normal gas (placebo, ambient air 400 m above sea level) during a 60-minute recovery phase after oxidative stress-inducing exercise) completion comprising 30-minute treadmill running at an intensity corresponding to 75% of maximal oxygen uptake and squat jumps (5 sets × 10 repetitions). Before oxidative stress-inducing exercise and 10 minutes after the post-exercise gas inhalation, blood and urine samples were obtained and exercise performances (jumping ability; pedaling power output; muscle strength) were evaluated. Post-exercise HG inhalation attenuated the increase in urinary 8-hydroxydeoxyguanosine excretion rate (P < 0.05), a DNA oxidation marker, and the reduction in the countermovement jump height (P < 0.05), compared with Placebo inhalation. Other exercise performances and blood oxidative stress and muscle damage markers did not differ between HG and Placebo inhalation. Moreover, the increase in urinary 8-hydroxydeoxyguanosine excretion rate was significantly associated with countermovement jump performance reduction (r = –0.78, P < 0.01). These findings suggested that HG inhalation during post-exercise recovery period might improve exercise performance via reducing systemic oxidative damage. The study was approved by the Human Research Ethics Committee of the University of Yamanashi (approval No. H29-006) on June 28, 2017.


How to cite this article:
Shibayama Y, Dobashi S, Arisawa T, Fukuoka T, Koyama K. Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men.Med Gas Res 2020;10:155-162


How to cite this URL:
Shibayama Y, Dobashi S, Arisawa T, Fukuoka T, Koyama K. Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men. Med Gas Res [serial online] 2020 [cited 2021 Jan 22 ];10:155-162
Available from: https://www.medgasres.com/article.asp?issn=2045-9912;year=2020;volume=10;issue=4;spage=155;epage=162;aulast=Shibayama;type=0