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RESEARCH ARTICLE
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Ozone for the treatment of temporomandibular joint disorders: a systematic review and meta-analysis


1 Laboratorio de Medicina Complementaria, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca, México
2 Programa de Doctorado en Biociencias, Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca, México
3 School of Public Health, Imperial College London, London, UK
4 Facultad de Derecho, Universidad Autónoma Nacional de México, Cuidad de México, México
5 Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR), Unidad Oaxaca, Instituto Politécnico Nacional, Oaxaca, México
6 Cátedras CONACyT – Facultad de Odontología; Laboratorio de Biomateriales, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca, México

Correspondence Address:
Liliana Argueta-Figueroa,
Cátedras CONACyT – Facultad de Odontología; Laboratorio de Biomateriales, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca
México
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2045-9912.345174

Temporomandibular joint disorders (TMD) generate pain and difficulties for mouth opening affecting the patients’ quality of life. Ozone is an emerging therapy that has been proposed as a potential treatment, due to that, the evidence about its efficacy should be reviewed. Therefore, this work aimed to conduct a comprehensive systematic review to address the efficacy of ozone therapy for the treatment of pain and limited mouth opening in patients with TMD. The design of the included studies was clinical trials and observational studies, whereas, a series of cases, in vivo, and in vitro studies were excluded. The search was performed in PubMed, ClinicalTrials, Web of Science, and Scopus. Gray literature was searched at Google Scholar. Relevant data of all included studies were recorded. The risk of bias (using RoB 2) and the quality (using Grading of Recommendations Assessment, Development, and Evaluation) assessments were carried out. Metaanalyses using random-effects models of pain and maximal mouth opening data were performed. This review included 8 studies with 404 participants suffering limited function and pain related to TMD. At the overall bias of the studies, 25% exhibited some concerns and 75% had high risk; and the quality of the studies was low. The analysis of the included studies suggests that ozone therapy can diminish pain and improve the maximal mouth opening in TMD patients. However, there is no conclusive evidence of ozone therapy as a superior treatment for TMD compared with occlusal splint and pharmacotherapy.


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    -  Torres-Rosas R
    -  Marcela Castro-Gutiérrez ME
    -  Flores-Mejía LA
    -  Torres-Rosas EU
    -  Nieto-García RM
    -  Argueta-Figueroa L
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