Figure 8: Various fluorescent probes employed with different strategies to detect NO. Note: Above: design strategy of ADNO probe; below: two-photon microscopy image of NO in ADNO-labeled NIH3T3 cells and ADNO-labeled cells treated with SNOC (S-nitrocysteine, a NO donor). Adapted from Liu et al. (B) Mito-DHP probe specifically targeting mitochondria for endogenous and exogenous produced NO by stimulated RAW264.7 murine macrophage and HepG2 cells, respectively. Adapted from Gao et al. (C) Gal-RhB sensor yielding fluorescent image of hepatocellular NO in Zebrafish. Adapted from Zhang et al. ADNO: (2-(α-(3,4-diaminophenoxy)acetyl)-6-(dimethylamino)naphthalene); NO: nitric oxide; Gal-RhB: a hepatocyte targeting fluorescent sensor.