Figure 6: Various fluorescent compounds used for imaging of NO. Note: (A) 2,3-Diaminonaphthalene after reaction with nitric oxide (NO) coverts into fluorescent triazole form. Adapted from Hong et al. (B) Overview of Danio rerio (Zebrafish model) indicates the fluorescent labeling of organs with Caudal fin (yellow), the notochord (purple), the cleithrum (orange) and the heart (blue). Adapted from Lepiller et al. (C) NO distribution in B16-F10 tumors grown in the cranial window in mouse, left: microangiography using tetramethylrhodamine-dextran; middle and right: pseudo-color representation of DAF-2T microfluorgraphs. Color bar represents the calibration of the fluorescence intensity with the known concentrations of DAF-2. Adapted from Kashiwagi et al. (D) Left: fluorescent image of DAR-4M loaded endothelial cells at 10 minutes after stimulation; right: fluorescence intensity strongly abolished by treatment with the agonist of the stimuli. Adapted from Kikuchi et al. (E) DAQ loaded cells and stimulated to produce NO imaged using confocal laser fluorescence microscopy, left: bright-field, middle: 488 nm excitation; right: 543 nm excitation. Adapted from Galindo et al. (F) Bright field and fluorescence images of activated PC12 cells loaded with 1,3,5,7-tetramethyl-2,6-dicarbethoxy-8-(3′,4′ -diaminophenyl)-difluoroboradiaza-s-indacence (TMDCDABODIPY) in the presence of arginine. Adapted from Chen et al. (G–J) Agents used for fluorescent based NO-sensing. Adapted from Hong et al.