Figure 13: General reaction of hemoglobin and deoxyhemoglobin with NO and MR imaging of NO in liver and brain. Note: (A, B) Reaction mechanisms of oxygenated (A) and deoxygenated (B) hemoglobin with nitric oxide (NO) for generation of paramagnetic methemoglobin and nitrosyl hemoglobin for magnetic resonance imaging. (C) T1 weighted magnetic resonance imaging of the axial pane of Wistar rat’s liver before injection and 60 minutes after injection of spin trap of (MGD)2-Fe(II)-NO. Adapted from Fujii et al. (D) Functional magnetic resonance imaging of healthy subject’s brain before and after intravenous administration of ascorbic acid. Adapted from Di Salle et al. MGD: N-methyl-D-glucamine dithiocarbamate; A: anterior; P: posterior ; L: left; R: right.