Figure 1: T2-weighted imaging (T2WI) identified lesion at 24 hours (hrs) post repetitive mild juvenile traumatic brain injury (rmjTBI). Note: (A) Representative T2WI images revealed hyperbaric oxygen (HBO) protection against the cumulative brain tissue damages including edema (hyperintensity) and hemorrhage (hypointensity) 24 hrs after repetitive injury (arrows). Lines indicate the locations of craniotomy. (B) Quantifying T2WI-derived lesion showed the significant increases in cortical lesion volumes at 24 hrs after the rmjTBI, which was reduced by HBO treatment. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, vs. sham group (one-way analysis of variance followed by Student-Newman-Keuls post hoc test). rmTBI: Repetitive mild traumatic brain injury.