Medical Gas Research

COMMENTARY
Year
: 2016  |  Volume : 6  |  Issue : 3  |  Page : 174--176

Hypoxia therapy--a new hope for the treatment of mitochondrial dysfunctions


Jun-long Huang1, Anatol Manaenko2, Zhou-heng Ye4, Xue-jun Sun4, Qin Hu3 
1 Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai; Department of Naval Aviation, the Second Military Medical University, Shanghai, China
2 Departments of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany
3 Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Correspondence Address:
Qin Hu
Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai
China

Mitochondrial dysfunctions are characteristic features of numerous diseases and play a critical role in disease pathogenesis. Despite intensive research in this area, there are no approved therapies that directly target mitochondria. Recently a study by Jain et al. from Massachusetts General Hospital, USA reported the effectiveness of hypoxia for treatment of mitochondrial disease in mice. In this commentary, we summarized the potential mechanisms underlying the therapeutic effects of hypoxia on mitochondrial dysfunction, and clinical limitations of hypoxia as a therapy for human patients. We hope that our concerns will be helpful for further clinical studies addressing moderate hypoxia in mitochondrial dysfunction.


How to cite this article:
Huang Jl, Manaenko A, Ye Zh, Sun Xj, Hu Q. Hypoxia therapy--a new hope for the treatment of mitochondrial dysfunctions.Med Gas Res 2016;6:174-176


How to cite this URL:
Huang Jl, Manaenko A, Ye Zh, Sun Xj, Hu Q. Hypoxia therapy--a new hope for the treatment of mitochondrial dysfunctions. Med Gas Res [serial online] 2016 [cited 2017 Nov 23 ];6:174-176
Available from: http://www.medgasres.com/article.asp?issn=2045-9912;year=2016;volume=6;issue=3;spage=174;epage=176;aulast=Huang;type=0