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REVIEW
Year : 2019  |  Volume : 9  |  Issue : 4  |  Page : 229-231

The role of oxygen in cluster headache


1 Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
2 Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

Correspondence Address:
Hai-Feng Lu
Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
China
Hong-Ru Zhao
Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2045-9912.273961

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High-flow oxygen inhalation is one of the most effective acute treatments for cluster headache. The therapy was first described for the treatment of cluster headache in 1952 by Horton, and has exhibited some advantages and efficacy compared to other acute medicines. The mechanism is not very clear, but some evidence has demonstrated its relationship to the trigeminovascular system and neuroinflammation. High-flow oxygen inhalation via a non-rebreather mask during cluster headache attacks has been widely recommended. Patients with frequent attacks and/or intolerance to drugs may prefer the oxygen treatment.


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