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RESEARCH ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 4  |  Page : 171-175

Effects of nitric oxide donor N,N’-di-sec-butyl-N,N’-dinitroso-1,4-phenylenediamine on the expression of interferon-gamma in tumor infiltrating lymphocytes


1 Department of Reproductive Medicine Center, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen; The State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou; Department of Urology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, China
2 The State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou; Department of Urology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, China
3 Department of Reproductive Medicine Center, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong Province, China

Correspondence Address:
Jing Fan
Department of Reproductive Medicine Center, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen; The State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou; Department of Urology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province
China
Xue-Mei Li
Department of Reproductive Medicine Center, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2045-9912.273954

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Nitric oxide (NO) has been proven to be a key regulator in the mammalian immune response, such as the innate and adaptive immune responses to tumors. The messenger NO involves T helper cell differentiation and lymphocyte biofunctions. In this study, we employed N,N’-di-sec-butyl-N,N’-dinitroso-1,4-phenylenediamine as NO donor and released NO around tumor infiltrating lymphocytes in vitro by short-time blue light irradiation. The interferon-γ secretion of tumor infiltrating lymphocytes was investigated to study the functional changes caused by the accurate spatio-temporal delivery of NO. The downregulation of interferon-γ in tumor infiltrating lymphocytes after NO treatment indicates promising biological applications to potentially play a role in the treatment of autoimmune diseases. The study was approved by the Medical Ethics Committee of the Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University, China (approved No. 065) on February 12, 2018.


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