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LETTER TO EDITOR
Year : 2018  |  Volume : 8  |  Issue : 4  |  Page : 185

The role of hydrogen sulfide in dentistry


Department of Dentistry, Government Taluk Head Quarters Hospital, Malappuram, India

Date of Submission02-Oct-2018
Date of Acceptance06-Nov-2018
Date of Web Publication9-Jan-2019

Correspondence Address:
Thorakkal Shamim
Department of Dentistry, Government Taluk Head Quarters Hospital, Malappuram
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2045-9912.248272

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How to cite this article:
Shamim T. The role of hydrogen sulfide in dentistry. Med Gas Res 2018;8:185

How to cite this URL:
Shamim T. The role of hydrogen sulfide in dentistry. Med Gas Res [serial online] 2018 [cited 2019 May 27];8:185. Available from: http://www.medgasres.com/text.asp?2018/8/4/185/248272

Dear Editor,

Till this date, hydrogen sulfide has shown applications in dentistry related to halitosis. This letter addresses recent updates about hydrogen sulfide in dentistry other than halitosis with emphasis on studies done in dental specialties, periodontology and orthodontics.

The hydrogen sulfide produced by Porphyromonas gingivalis enhances methyl mercaptan-induced pathogenicity in mouse abscess formation and plays a supportive role in inflammation caused by methionine γ-lyase.[1] Exogenous hydrogen sulfide inhibits oral mucosal wound-induced macrophage activation via the nuclear factor-κB pathway that may aid in controlling inflammation associated with mucosal wounds.[2] Hydrogen sulfide induces the formation of nucleotide-binding domain and leucine-rich repeat containing protein 3 inflammasome-dependent interleukin 1β and interleukin 18 secretion in human mononuclear leukocytes in vitro in the pathogenesis of periodontitis.[3] Endogenous hydrogen sulfide is produced in human gingival tissue with expression of cystathionine β-synthase and cystathionine γ-lyase.[4] Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway.[5]

Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement by enhancing alveolar bone remodeling as a result of an increased osteoclastic activity and osteogenesis.[6] Hydrogen sulfide may also be involved in the periodontal tissue remodeling during the orthodontic tooth movement as a result of accelerated periodontal ligament cell differentiation, tissue mineralization, bone formation and collagen synthesis.[6] It can be inferred that more collaborative and extensive research in ultrastructural level should be done to uncover the therapeutic options of hydrogen sulfide in dentistry in future.

 
  References Top

1.
Nakamura S, Shioya K, Hiraoka BY, et al. Porphyromonas gingivalis hydrogen sulfide enhances methyl mercaptan-induced pathogenicity in mouse abscess formation. Microbiology. 2018;164:529-539..  Back to cited text no. 1
    
2.
2. Zhuang R, Guo L, Du J, Wang S, Li J, Liu Y. Exogenous hydrogen sulfide inhibits oral mucosal wound-induced macrophage activation via the NF-κB pathway. Oral Dis. 2018;24:793-801.  Back to cited text no. 2
    
3.
Basic A, Alizadehgharib S, Dahlén G, Dahlgren U. Hydrogen sulfide exposure induces NLRP3 inflammasome-dependent IL-1β and IL-18 secretion in human mononuclear leukocytes in vitro. Clin Exp Dent Res. 2017;3:115-120.  Back to cited text no. 3
    
4.
4. Chun-Mei J, Wu C, Guo-Liang M, Yue G, Ning C, Ji Y. Production of endogenous hydrogen sulfide in human gingival tissue. Arch Oral Biol. 2017;74:108-113.  Back to cited text no. 4
    
5.
Yang R, Yu T, Liu D, Shi S, Zhou Y. Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway. Stem Cell Res Ther. 2018;9:62.  Back to cited text no. 5
    
6.
Pu H, Hua Y. Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement. Mol Med Rep. 2017;16:9415-9422.  Back to cited text no. 6
    

Copyright transfer agreement: The Copyright License Agreement has been signed by the author before publication.
Plagiarism check: Checked twice by iThenticate.
Peer review: Externally peer reviewed.




 

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