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REVIEW
Year : 2018  |  Volume : 8  |  Issue : 1  |  Page : 24-28

Hyperbaric oxygen therapy as adjunctive strategy in treatment of glioblastoma multiforme


1 Department of Neurosurgery; Department of Basic Sciences, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA, USA
2 Department of Neurosurgery, School of Medicine, Loma Linda University, Loma Linda, CA, USA
3 Department of Neurosurgery; Department of Basic Sciences, Division of Physiology; Department of Anesthesiology, School of Medicine, Loma Linda University, Loma Linda, CA, USA

Correspondence Address:
Lei Huang
Department of Neurosurgery; Department of Basic Sciences, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2045-9912.229600

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Glioblastoma multiforme (GBM) is the most common type of malignant intracranial tumor in adults. Tumor tissue hypoxia, high mitotic rate, and rapid tumor spread account for its poor prognosis. Hyperbaric oxygen therapy (HBOT) may improve the sensitivity of radio-chemotherapy by increasing oxygen tension within the hypoxic regions of the neoplastic tissue. This review summarizes the research of HBOT applications within the context of experimental and clinical GBM. Limited clinical trials and preclinical studies suggest that radiotherapy immediately after HBOT enhances the effects of radiotherapy in some aspects. HBOT also is able to strengthen the anti-tumor effect of chemotherapy when applied together. Overall, HBOT is well tolerated in the GBM patients and does not significantly increase toxicity. However, HBOT applied by itself as curative strategy against GBM is controversial in preclinical studies and has not been evaluated rigorously in GBM patients. In addition to HBOT favorably managing the therapeutic resistance of GBM, future research needs to focus on the multimodal or cocktail approaches to treatment, as well as molecular strategies targeting GBM stem cells.


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