• Users Online: 130
  • Home
  • Print this page
  • Email this page
RESEARCH ARTICLE
Year : 2017  |  Volume : 7  |  Issue : 4  |  Page : 256-259

A physiologically based model for denitrogenation kinetics


1 Medical R&D, Air Liquide Santé International, Centre de Recherche Claude-Delorme, Jouy-en-Josas, France; Department of Mechanical Engineering, Lafayette College, Easton, PA, USA
2 Medical R&D, Air Liquide Santé International, Centre de Recherche Claude-Delorme, Jouy-en-Josas, France

Correspondence Address:
Ira Katz
Medical R&D, Air Liquide Santé International, Centre de Recherche Claude-Delorme, Jouy-en-Josas, France; Department of Mechanical Engineering, Lafayette College, Easton, PA, USA

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2045-9912.222449

Rights and Permissions

Under normal conditions we continuously breathe 78% nitrogen (N2) such that the body tissues and fluids are saturated with dissolved N2. For normobaric medical gas administration at high concentrations, the N2 concentration must be less than that in the ambient atmosphere; therefore, nitrogen will begin to be released by the body tissues. There is a need to estimate the time needed for denitrogenation in the planning of surgical procedures. In this paper we will describe the application of a physiologically based pharmacokinetic model to denitrogenation kinetics. The results are compared to the data resulting from experiments in the literature that measured the end tidal N2 concentration while breathing 100% oxygen in the form of moderately rapid and slow compartment time constants. It is shown that the model is in general agreement with published experimental data. Correlations for denitrogenation as a function of subject weight are provided.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed123    
    Printed7    
    Emailed0    
    PDF Downloaded24    
    Comments [Add]    

Recommend this journal