• Users Online: 41
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2016  |  Volume : 6  |  Issue : 4  |  Page : 187-193

Neuroprotective effect of hyperbaric oxygen therapy in a juvenile rat model of repetitive mild traumatic brain injury


1 Department of Anesthesiology, School of Medicine, Loma Linda University, Loma Linda, CA; Department of Basic Sciences, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA, USA
2 Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA; Cell, Molecular and Developmental Biology Program, University of California Riverside, Riverside, CA; Division of Interdisciplinary Studies, School of Behavioral Health, Loma Linda University, Loma Linda, CA, USA
3 Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA
4 Department of Anesthesiology, School of Medicine, Loma Linda University, Loma Linda, CA; Department of Basic Sciences, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA; Department of Neurosurgery, Loma Linda University, Loma Linda, CA, USA

Correspondence Address:
John H Zhang
Department of Anesthesiology, School of Medicine, Loma Linda University, Loma Linda, CA; Department of Basic Sciences, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA; Department of Neurosurgery, Loma Linda University, Loma Linda, CA
USA
Login to access the Email id

Source of Support: This study was supported by funding from Loma Linda University GRASP award (LH and AO, 699314-4526)., Conflict of Interest: None


DOI: 10.4103/2045-9912.196900

Rights and Permissions

Repetitive mild traumatic brain injury (rmTBI) is an important medical concern for adolescent athletes that can lead to long-term disabilities. Multiple mild injuries may exacerbate tissue damage resulting in cumulative brain injury and poor functional recovery. In the present study, we investigated the increased brain vulnerability to rmTBI and the effect of hyperbaric oxygen treatment using a juvenile rat model of rmTBI. Two episodes of mild cortical controlled impact (3 days apart) were induced in juvenile rats. Hyperbaric oxygen (HBO) was applied 1 hour/day × 3 days at 2 atmosphere absolute consecutively, starting at 1 day after initial mild traumatic brain injury (mTBI). Neuropathology was assessed by multi-modal magnetic resonance imaging (MRI) and tissue immunohistochemistry. After repetitive mTBI, there were increases in T2-weighted imaging-defined cortical lesions and susceptibility weighted imaging-defined cortical microhemorrhages, correlated with brain tissue gliosis at the site of impact. HBO treatment significantly decreased the MRI-identified abnormalities and tissue histopathology. Our findings suggest that HBO treatment improves the cumulative tissue damage in juvenile brain following rmTBI. Such therapy regimens could be considered in adolescent athletes at the risk of repeated concussions exposures.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1279    
    Printed82    
    Emailed0    
    PDF Downloaded538    
    Comments [Add]    
    Cited by others 4    

Recommend this journal