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COMMENTARY
Year : 2016  |  Volume : 6  |  Issue : 3  |  Page : 174-176

Hypoxia therapy--a new hope for the treatment of mitochondrial dysfunctions


1 Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai; Department of Naval Aviation, the Second Military Medical University, Shanghai, China
2 Departments of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany
3 Department of Naval Aviation, the Second Military Medical University, Shanghai, China
4 Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Correspondence Address:
Qin Hu
Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2045-9912.191365

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Mitochondrial dysfunctions are characteristic features of numerous diseases and play a critical role in disease pathogenesis. Despite intensive research in this area, there are no approved therapies that directly target mitochondria. Recently a study by Jain et al. from Massachusetts General Hospital, USA reported the effectiveness of hypoxia for treatment of mitochondrial disease in mice. In this commentary, we summarized the potential mechanisms underlying the therapeutic effects of hypoxia on mitochondrial dysfunction, and clinical limitations of hypoxia as a therapy for human patients. We hope that our concerns will be helpful for further clinical studies addressing moderate hypoxia in mitochondrial dysfunction.


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