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REVIEW
Year : 2016  |  Volume : 6  |  Issue : 3  |  Page : 154-163

Brain globins in physiology and pathology


Center for Neuroscience Discovery, University of North Texas Health Science Center, Fort Worth, TX, USA

Correspondence Address:
Shao-hua Yang
Center for Neuroscience Discovery, University of North Texas Health Science Center, Fort Worth, TX
USA
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Source of Support: This work was partly supported by the National Institutes of Health, China, No. R01NS054651 (SY) and R01NS088596 (SY)., Conflict of Interest: None


DOI: 10.4103/2045-9912.191361

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Globins are globular proteins for either transport or storage of oxygen which are critical for cellular metabolism. Four globins have been identified in rodent and human brains. Among them, neuroglobin, cytoglobin and hemoglobin chains are constitutively expressed in normal brain, while myoglobin is only expressed in some neurological disorders. Studies on the molecular structure, expression and functional features of these brain globins indicated that they may play crucial roles in maintenance of neural cell survival and activity, including neurons and astrocytes. Their regulation in neurological disorders may help thoroughly understand initiation and progression of ischemia, Alzheimer's disease and glioma, etc. Elucidation of the brain globin functions might remarkably improve medical strategies that sustain neurological homeostasis and treat neurological diseases. Here the expression pattern and functions of brain globins and their involvement in neurological disorders are reviewed.


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