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REVIEW
Year : 2016  |  Volume : 6  |  Issue : 2  |  Page : 79-84

The role of hydrogen sulfide in stroke


Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

Correspondence Address:
Gang Chen
Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
China
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Source of Support: This work was supported by a grant from Suzhou Key Medical Center of China, No. Szzx201501; grants from the National Natural Science Foundation of China, No. 81571115, 81422013, and 81471196; a grant from Scientific Department of Jiangsu Province, China, No. BL2014045; grants from Suzhou Government, China, No. LCZX201301, SZS201413, and SYS201332; and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions, China., Conflict of Interest: None


DOI: 10.4103/2045-9912.184717

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Stroke is a kind of acute cerebrovascular disease characterized by the focal lack of neurological function, including ischemic stroke and hemorrhagic stroke. As society ages rapidly, stroke has become the second leading cause of disability and death, and also become the main threat to human health and life. In recent years, findings from increasing animal and clinical trials have supplied scientific evidences for the treatment of stroke. Hydrogen sulfide (H 2 S), which has always been seen as a toxic gas, now has been thought to be the third gaseous signaling molecule following nitric oxide and carbon monoxide. Accumulating evidences indicate that H 2 S plays an important role in stroke. Given that its neuroprotective effect is dose-dependent, only when its concentration is relatively low, H 2 S can yield the neuroprotection, while high dose may lead to neurotoxicity. All these study results suggest that H 2 S may offer a new promising application for the therapy of stroke. Here, our review will present the role of H 2 S in stroke from its mechanism to animal and clinical studies.


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