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REVIEW
Year : 2016  |  Volume : 6  |  Issue : 1  |  Page : 48-54

Hydrogen therapy: from mechanism to cerebral diseases


Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

Correspondence Address:
Gang Chen
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province
China
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Source of Support: Funding: This work was supported by a grant from Suzhou Key Medical Center of China (No. Szzx201501), grants from the National Natural Science Foundation of China (No. 81571115, 81422013, and 81471196), a grant from the Scientific Department of Jiangsu Province of China (No. BL2014045), a grant from Suzhou Government of China (No. LCZX201301, SZS201413, and SYS201332), and A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions., Conflict of Interest: None


DOI: 10.4103/2045-9912.179346

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The medicinal value of hydrogen (H 2 ) was ignored prior to research illustrating that inhalation of 2% H 2 can significantly decrease the damage of cerebral ischemia/reperfusion caused by oxidative stress via selective elimination of hydroxyl freebase (OH) and peroxynitrite anion (ONOOˉ). Subsequently, there have been numerous experiments on H 2 . Most research and trials involving the mechanisms underlying H 2 therapy show the effects of antioxygenation, anti-inflammation, and anti-apoptosis. Among quantities of diseases related with H 2 therapy, the brain disease is a hotspot as brain tissue and cell damage are easier to be induced by oxidative stress and other stimulations. In this review, emphasis is on stroke, traumatic brain injuries, and degenerative diseases, such as Alzheimer's disease and Parkinson's disease. Taking into account the blood-brain barrier, penetrability, possible side effects, and the molecular properties of H 2 within a single comprehensive review should contribute to advancing both clinical and non-clinical research and therapies. A systematic introduction of H 2 therapy with regards to mechanisms and cerebral diseases both in animal and human subjects can make it easier to comprehend H 2 therapy and therefore provide the basis for further clinical strategy.


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